Iron‐Catalyzed Cross‐Coupling of Propargyl Ethers with Grignard Reagents for the Synthesis of Functionalized Allenes and Allenols

Herein we disclose an iron-catalyzed cross-coupling reaction of propargyl ethers with Grignard reagents. The was demonstrated to be stereospecific and allows for a facile preparation optically active allenes via efficient chirality transfer. Various tri- tetrasubstituted fluoroalkyl can obtained in good excellent yields. In addition, reagents α-alkynyl oxetanes tetrahydrofurans is disclosed herein, which constitutes straightforward approach towards fully substituted β- or γ-allenols, respectively.